Offre d'emploi : Head of Target Discovery and Validation (M/F)

6 jours restants

Gosselies, Charleroi
lundi 20 décembre 2021
Date limite
jeudi 3 février 2022
Type de contrat
Temps de travail
Temps plein

iTeos Therapeutics is a publicly-held (NASDAQ: ITOS), clinical-stage biopharmaceutical company dedicated to extending and improving the lives of cancer patients by designing and developing next generation immunotherapies. 

Based in Gosselies, Belgium and Cambridge, MA, iTeos Therapeutics was founded out of the Ludwig Institute for Cancer Research (LICR) and the de Duve Institute (UCLouvain) in 2011.

In March 2020, the Company completed a $125 million Series B2 financing, and in July 2020, we completed our IPO raising over $230million of gross proceeds. In June 2021, iTeos entered into a transformative $2.145 billion co-development and co-commercialization agreement with GSK for EOS-448, iTeos’s anti-TIGITmonoclonal antibody. As a well-capitalized biotech company iTeos is positioned to continue to develop our clinical pipeline and maintain our investments in our discovery research team to leverage our fantastic science to improve the lives of cancer patients.

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iTeos Therapeutics is now a world-class biotech in cancer immunotherapy. To carry on its growth, expand its pipeline and reinforce its team, iTeos Therapeutics is looking for a (m/f) Head of Target Discovery and Validation.



To carry on its growth, expand its pipeline and reinforce its team, iTeos Therapeutics is looking for a Head of Target Discovery and Validation. This is an exciting opportunity to play a central role in shaping the pipeline of an ambitious, science-driven biotech company. 

The role would suit a highly motivated and energetic scientist looking to make a substantial contribution to the advancement of novel approaches to harnessing the immune system to tackle cancer. The right candidate will have experience in immuno-oncology and will have the overall responsibility to recommend projects for progression to lead identification and/or IND enabling studies. In addition, the candidate will have an ability to engage and collaborate across organizational boundaries with an entrepreneurial attitude by acting with urgency and agility. 

Key responsibilities:

  • In collaboration with colleagues in BD and R&D, review emerging targets and assets in the IO space with a view to identifying opportunities to build the pipeline.
  • Execute rigorous validation of novel IO opportunities emanating from academia, VC, biotech including early research projects.
  • Manage cell biologists, immunologists and a screening team.
  • Drive the iTeos Discovery process.
  • Set the prioritization of projects within your team in line with the company strategy and in collaboration and matrix management across functional groups at iTeos including bioinformatics, medicinal chemistry, biology, clinical, translational medicine and business development.
  • Provide clear recommendations to senior (executive) teams for the promotion of projects to the drug discovery stage.
  • Act as an expert in industry trends in oncology including awareness of competitor datasets in iTeos areas of strategic focus.



  • PhD and/or post-doc in (Tumour) Immunology and 5-10+ years in oncology life sciences industry.
  • Proven scientific track record in early drug discovery projects with emphasis on early drug discovery in multiple target classes from hit qualification to lead identification phase with >5 years in the pharmaceutical/biotechnology sector.
  • Experience in the following techniques: Flow cytometry, immune based cell assays, biochemical and biophysical assays, cell-based assays for drug discovery high-throughput screening, automation, target engagement assays, RNAi, CRISPR, immune based oncology models.
  • Proven innovation driven leadership abilities in a drug discovery environment with demonstrable knowledge of pre-clinical and clinical R&D.
  • Extensive experience in pharmaceutical R&D, demonstrating international experience in multiple cultures and drug discovery / clinical environments.
  • Demonstrated ability to lead and influence experienced internal/external professionals.
  • A commitment to rigorous data analyses and interpretation.
  • Excellent communicator who takes responsibility for decisions made. Role model engagement and commitment.
  • Demonstrated ability to both lead and be a team player in an interdisciplinary team-oriented environment.
  • Fluency in written and spoken English is essential.



  • A stimulating position within a high-potential innovative biotech company.
  • The opportunity to work in a science-driven, dynamic, respectful and professional environment.
  • A challenging scientific and business growth in which you get to bring your knowledge and skills.
  • A permanent contract with an attractive salary package in line with the position responsibilities and your experience.



Send your CV together with an adapted cover letter via or to the following address:

Your application and related information will remain strictly confidential.

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